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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(39)

Glyoxalase

(2)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(33)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(88)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(46)

Stearoyl-CoA Desaturase (SCD)

RAR/RXR

The retinoic acid receptor (RAR) and the retinoid X receptor (RXR) are nuclear receptor which can also act as a ligand-activated transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid, retinoid active derivatives of Vitamin A. As with other type II nuclear receptors, RAR heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements known as retinoic acid response elements (RAREs) complexed with corepressor protein. Due to RAR/RXR heterodimers acting as subtrates to the non steroid hormone ligand retinoid they are extensively involved in cell differentiation, proliferation, and apoptosis.

Filter HomeSignaling PathwaysMetabolismRAR/RXR

Bigelovin

TN67353668-14-2

Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.

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Latanoprost

T2528130209-82-4

Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.

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Cited

PA452

T16425457657-34-0

PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1 Th2 development.

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K-8012

T242401346513-17-4In house

K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.

$117

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SR11237

T23383146670-40-8

SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.

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K-80003

T117341292821-90-9In house

K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.

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BMS-185354

T205728110952-22-2

BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.

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10-14 weeks

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DC360

T2045622324152-25-0

DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.

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10-14 weeks

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ZSH-512

T2041032923210-02-8

ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.

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10-14 weeks

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IRX5010

T205243856683-59-5

IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.

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10-14 weeks

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ZSH-2208

T2054342131803-75-1

ZSH-2208, an analogue of retinoic acid A, exerts strong anti-tumor effects on regenerative stem cells (TRCs) in esophageal squamous cell carcinoma (ESCC) via the RARγ-TNFAIP3 pathway.

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10-14 weeks

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